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Symbol
Name
ID 		Vac14
Vac14 homolog (S. cerevisiae)
MGI:2157980
Phenotype annotations related to nervous system
Darker colors indicate more annotations
Human Phenotypes
Dysphagia
Spasticity
Difficulty walking
Frequent falls
Striatal T2 hyperintensity
Degeneration of the striatum
Symmetric lesions of the basal ganglia
Dysdiadochokinesis
Incoordination
Poor motor coordination
Slurred speech
Bradykinesia
Choreoathetosis
Paroxysmal choreoathetosis
Chorea
Clonus
Myoclonus
Tremor
Babinski sign
Dysarthria
Motor tics
Intellectual disability
Brisk reflexes
Lower limb hyperreflexia
Hypokinesia
Dystonia
Lingual dystonia
Gait disturbance
Headache
Developmental regression
Developmental stagnation
Global developmental delay
Disease(s) Associated with VAC14
striatonigral degeneration

Mouse Phenotypes
increased forebrain apoptosis
increased hindbrain apoptosis
increased midbrain apoptosis
hydrocephaly
enlarged brain ventricles
enlarged lateral ventricles
abnormal medulla oblongata morphology
abnormal midbrain morphology
abnormal superior colliculus morphology
abnormal pons morphology
abnormal hypothalamus morphology
abnormal thalamus morphology
abnormal hippocampus morphology
abnormal cerebral cortex morphology
abnormal olfactory bulb morphology
abnormal cerebellum morphology
brain lesion
astrocytosis
gliosis
abnormal trigeminal ganglion morphology
abnormal sensory ganglion morphology
abnormal dorsal root ganglion morphology
spongiform encephalopathy
Availability Mouse Genotype
Vac14Gt(RRP155)Byg/Vac14Gt(RRP155)Byg
Vac14ingls/Vac14ingls
Vac14Gt(RRP155)Byg/Vac14ingls
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory